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Healthcare professionals are advised to consider alternative combination strategies that target different pathophysiological defects in type 2 diabetes for example, combining a GLP-1 RA with an SGLT2 inhibitor or metformin rather than stacking two incretin-based therapies

The results highlight coordinated activation of GLP-1R, GIPR, and GCGR, illustrating how integrated regulation of appetite suppression, insulin sensitivity, and energy expenditure is reshaping next-generation metabolic drug development

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fumigatus and has been demonstrated to be essential for gliotoxin biosynthesis (Figure 3) (Schrettl et al., 2010

This review navigates the intricate relationship between MASLD and CKD, spotlighting their worldwide prevalence and shared risk factors